Fig. 2: Structure of the MuvBN subcomplex. | Nature Communications

Fig. 2: Structure of the MuvBN subcomplex.

From: The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes

Fig. 2

a Overall structural model. b Alignment of LIN9 sequences from H. sapiens, C. japonica, D. rerio, D. melanogaster, S. purpuratus, and C. intestinalis. The (*) marks residues that contact RBAP48, the (.) marks residues that contact LIN37, and the (@) marks residues that contact both. c Close-up view of one interface between LIN9 and RBAP48. d Location of histone H3 and histone H4 peptide binding sites on RBAP48. When bound to LIN9, the H4 sites is blocked while the H3 site is mostly accessible. The model was generated from PDB IDs: 2YBA and 3CFV.

Back to article page