Fig. 3: Scope of the 4-exo-dig radical cyclization of ynamides to azetidines. | Nature Communications

Fig. 3: Scope of the 4-exo-dig radical cyclization of ynamides to azetidines.

From: A general synthesis of azetidines by copper-catalysed photoinduced anti-Baldwin radical cyclization of ynamides

Fig. 3

Reaction conditions: ynamide 1 (0.2 mmol), [Cu(bcp)DPEphos]PF6 (5 mol%), (i-Pr)2NEt (2 mmol), MeCN (0.1 M), rt, 60 h. Isolated yields are provided and Z/E ratios were determined by 1H NMR analyses of the crude reaction mixtures. * from N-bromoethyl-ynamide 1aBr. ** during 120 h.

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