Fig. 6: Chemical diversification of representative unsaturated azetidines.

a Hydrogenation of representative azetidines. b Post-functionalization of the exocyclic double bond of model azetidine 2a. Isolated yields are provided and dr were determined by 1H NMR analyses of the crude reaction mixtures. TFA trifluoroacetic acid, DTBP 2,6-di-tert-butylpyridine and MS molecular sieves.