Fig. 4: LTR5Hs may serve as TEENhancers in hPGCLCs. | Nature Communications

Fig. 4: LTR5Hs may serve as TEENhancers in hPGCLCs.

From: Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections

Fig. 4

A, B Top enriched motifs within NANOG (A) and SOX17 (B) ChIP-seq peaks in hPGCLCs. Hypergeometric test is performed using Homer77. C Heatmaps and metaplots of NANOG, TFAP2C, SOX17, and H3K27ac ChIP-seq signals in hESCs and hPGCLCs, and SOX15 CUT&Tag-seq signals in hPGCLCs over all LTR5Hs (n = 697) and HERVK (n = 262). D Screenshots for ATAC-seq signals, NANOG, TFAP2C, SOX17, and H3K27ac ChIP-seq signals in hESCs and hPGCLCs, and CUT&Tag-seq signals for SOX15 over LTR5Hs TEENhancers and their potential target genes (ST6GAL1, PRODH, and STOM).

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