Fig. 1: Overall structures of the MT1-Gi and MT2-Gi signaling complexes.
From: Structural basis of the ligand binding and signaling mechanism of melatonin receptors
a Cryo-EM density maps of the MT1-Gi and MT2-Gi complexes. The color code is as follows: MT1, blue; MT2, green; Gαi in MT1, purple; Gαi in MT2, yellow; Gβ, teal; Gγ, light green; scFV16, violet. b Cryo-EM structures of the MT1-Gi and MT2-Gi complexes. Left, 2-iodomelatonin-bound MT1-Gi; middle, ramelteon-bound MT1-Gi; right, ramelteon-bound MT2-Gi. The structures of the respective ligand and the melatonin molecule (right) are shown.
