Fig. 1: Manhattan plots showing results for meta-analyses of Intervertebral disc disorders (M51), dorsalgia (M54) and lumbar discectomy (LDHsurg). | Nature Communications

Fig. 1: Manhattan plots showing results for meta-analyses of Intervertebral disc disorders (M51), dorsalgia (M54) and lumbar discectomy (LDHsurg).

From: Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

Fig. 1

The P values (−log 10) from meta-analyses of the studied phenotypes are plotted (y-axis) against their respective positions on each chromosome (x-axis). a Intervertebral disc disorders IDD (M51), additive model (four cohorts; 58,854 cases, 922,958 controls), (b) Dorsalgia (M54), additive model (four cohorts, 119,110 cases, 909,847 controls), and (c) severe lumbar IDD defined by surgery (LDHsurg) (three cohorts; 9188 cases, 780,233 controls). P values are two sided and derived from a likelihood-ratio test. The gray and black dots represent SNPs not reaching genome-wide significance threshold weighted for variant impact18. The yellow dots represent genome-wide significant SNPs and the red dots represent genome-wide significant SNPs with moderate or high impact18 (Methods).

Back to article page