Fig. 2: Genes likely to associate with (a) IDD and (b) Dorsalgia. | Nature Communications

Fig. 2: Genes likely to associate with (a) IDD and (b) Dorsalgia.

From: Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

Fig. 2

Sequence variants associated with (a) IDD and (b) Dorsalgia for which functional evidence supports implication of genes in back pain. The variants listed are either protein-coding variants or affect mRNA expression (top cis-eQTL) as depicted by gray boxes (lof loss-of-function) (Supplementary Data 5–8). *Variants also associated in cis with mRNA of other genes (Supplementary Data 7,8). The meta-analyses were performed using logistic regression, the risk (odds ratio OR in yellow) of (a) IDD and (b) Dorsalgia are here shown for the risk-increasing allele and significance in blue. COL11A1 and GSDMC are not included in the figure as evidence for their association with back pain was derived differently as described in results.

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