Table 2 Variants associating with LDHsurg in GWAS meta-analysis of three cohorts; Iceland, UK Biobank and Finland (Ncases = 9188, Ncontrols = 780,323) compared to association with IDD (M51) in all four cohorts.

From: Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

Loci

rs name

EAa

Close gene

Annotation

Frqb

ORLDHsurg (95% CI)c

PLDHsurgc

OR IDD (95% CI)c

PIDDc

8q24.21

rs7833174

C

GSDMC

Regulatory region

23.4

0.85 (0.82, 0.88)

2.1 × 10−16

0.96 (0.95, 0.97)

7.2 × 10−14

10q22.1

rs4148948

G

CHST3

3′UTR

38.2

0.88 (0.85, 0.91)

4.1 × 10−14

0.92 (0.90, 0.93)

1.6 × 10−39

7p12.3

rs1723939

T

Near IGFBP3

Regulatory region

50.2

1.12 (1.08, 1.15)

1.4 × 10−11

1.06 (1.05, 1.07)

1.6 × 10−18

  1. aEffect allele (EA).
  2. bAverage frequency of effect allele in the three cohorts for which the surgical phenotype was available (Iceland, UKB, and Denmark).
  3. cOR and P value for an inverse-variance weighted meta-analysis of association results for three cohorts (LDHsurg) and all four cohorts (IDD).
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