Fig. 10: Sympathetic cholinergic fibres preserve HSC quiescence in endosteal BM niche.
From: Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis
1 Sympathetic cholinergic signals increase in the endosteal bone marrow after chemotherapy or irradiation. 2 Acetylcholine (ACh) is released by sympathetic fibres in the endosteal niche for haematopoietic stem cells (HSCs). 3 ACh activates α7 nicotinic ACh receptor (α7nAChR) and induces CXCL12 secretion by Nes-GFPhi cells enriched in HSC niche-forming mesenchymal stem cells (MSCs). 4 Cholinergic-induced CXCL12 promotes HSC quiescence and self-renewal.
