Fig. 2: 3M-052-Alum/OVA induces a global anti-viral innate immunity program in draining LN 1 day post-immunization.
From: A molecular atlas of innate immunity to adjuvanted and live attenuated vaccines, in mice
a UMAP embedding of 21,664 cells classified by cell type. b Scaled expression of cell-type-specific genes used to classify cells by type. c Number of upregulated (red) and downregulated (blue) genes in each cell type, FDR < 0.05 and absolute LogFC > 0.25. d Log fold change of genes from (c) across all cell types. Genes and cell types were k-means and hierarchically clustered. Functional groups of relevant gene clusters are highlighted. e BTMs significantly enriched (FDR < 0.001) after 1- day post-immunization with 3M-052-Alum/OVA. Overrepresentation analysis of the genes from (c) was used to determine significance. Adjusted P-values were measured using hypergeometric distribution with Benjamini Hochberg correction.
