Fig. 6: Summarized model TAZ protein was stabilized and activated by exercise training. | Nature Communications

Fig. 6: Summarized model TAZ protein was stabilized and activated by exercise training.

From: TAZ links exercise to mitochondrial biogenesis via mitochondrial transcription factor A

Fig. 6

Activated TAZ translocates into the nucleus and induces Rheb/Rhebl1 expression by binding to the TEAD transcription factor. During a resting period, elevated Rheb/Rhebl1 levels amplify TORC1 signalling for upregulating the translation of Tfam mRNA. Increased Tfam protein enhances mitochondrial biogenesis by the upregulation of mitochondrial DNA replication and mitochondria-encoded gene expression.

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