Fig. 3: Schematic of macaque challenge model and tissue sampling. | Nature Communications

Fig. 3: Schematic of macaque challenge model and tissue sampling.

From: Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis

Fig. 3

Macaques for challenge studies were divided into four antibody treatment groups, 10E8v4 unmodified, 10E8v4 LALA, 10E8v4 EFTAE, or isotype control mAb (DEN3). Antibody was subcutaneously delivered 3 days prior to a single high-dose mucosal SHIVSF162P3 challenge. Rectal and inguinal lymph node biopsies were collected on study day 5 and 14, respectively, PBMCs were collected every 14 days, and plasma collected weekly. Thirteen tissues representing diverse anatomical regions, detailed in Fig. 4m, were harvested on study day 63. Group colors are consistent throughout the manuscript. IR intrarectal, TCID50 50% tissue culture infectious dose, LN lymph node, PVL plasma viral load, PBMC peripheral blood mononuclear cells.

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