Fig. 7: MitoMISS ameliorates glucose toxicity with regard to organismal lifespan. | Nature Communications

Fig. 7: MitoMISS ameliorates glucose toxicity with regard to organismal lifespan.

From: Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis

Fig. 7

a Lifespan analysis of wild type animals upon MitoMISS with and without 5mM D-glucose supplementation. b–e Lifespan analysis of tissue-specific MitoMISS application. f Neuron-specific genetic inhibition of cco-1 100% and 10% diluted. Survival curves were compared with the Log-rank (Mantel–Cox) test (*** denotes P < 0.0001, ** denotes P < 0.001); detailed values are shown in Supplementary Table 2.

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