Fig. 2: Bioinformatic prediction of lapcin from the lap gene cluster. | Nature Communications

Fig. 2: Bioinformatic prediction of lapcin from the lap gene cluster.

From: Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis

Fig. 2

a The substrate of each lapcin A-domain was inferred by comparing the 10 residues that make up the substrate binding pocket of each lapcin A-domain with characterized NRPS A-domains (red, difference between lap and known substrate binding pockets). b The structure of lapcin was predicted bioinformatically based on the NRPS modules and accessory enzymes found in the lap gene cluster. c The predicted structure of lapcin.

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