Table 1 Lapcin activity against human cell lines.

From: Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis

Cancer type

IC50 (nM)

Cell line

Lapcin

Etoposide

Camptothecin

Colon cancer

 HT29

0.516

9,610

22.3

 Colo205

0.504

>54,400

95.7

 HCT116

923

>54,400

129

 SW480

37.2

26,900

284

Breast cancer

 MCF 7

35.1

333

>29,200

 HCC1806

212

3,330

19.6

Lung cancer

 A549

2.66

79.9

17.6

 NCI-H1299

0.0168

716

15.0

 NCI-H226

241

217

28.5

Other

 Hela (Cervical)

0.986

1,510

62.6

 U2OS (Bone)

1.29

1,840

172

Normal cell

 HEK293

48.4

729

19.2

  1. Note: IC50s were rounded to three significant figures. n = 3 biologically independent cells.
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