Fig. 2: Antibody evasion by Delta and Kappa variants. | Nature Communications

Fig. 2: Antibody evasion by Delta and Kappa variants.

From: Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants

Fig. 2

a Antibody-binding footprints, antibody binding as assessed by ELISA, and pseudovirus neutralisation for four anti-RBD antibodies (Ab1 - PDB ID: 7MJJ, Ab8 - PDB ID: 7MJH, S309 – PDB ID: 6WPS, and S2M11 – PDB ID: 7K43). Both ELISA and pseudovirus neutralisation assays were performed at least in technical duplicate and the mean is plotted. Error bars represent standard deviation. b As in a but for two anti-NTD antibodies (4A8 - PDB ID: 7C2L and 4–8 - PDB ID: 7LQV) Both ELISA and pseudovirus neutralisation assays were performed at least in technical duplicate and the mean is plotted. Error bars represent standard deviation. c Log fold dilutions of sera conferring 50% neutralisation (EC50) of pseudovirus harbouring wild-type, Kappa or Delta spikes, from patients post COVID19 and/or vaccination (n = 12 patients). Statistical significance was tested via the Wilcoxon matched-pairs test (two-tailed). Patient-derived sera sample information and raw pseudovirus neutralisation data are presented in Supplementary Fig. 15. Source data are provided as a Source Data file.

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