Fig. 1: Our inspiration from nature and previous work. | Nature Communications

Fig. 1: Our inspiration from nature and previous work.

From: Bioinspired desaturation of alcohols enabled by photoredox proton-coupled electron transfer and cobalt dual catalysis

Fig. 1

a 14α-Demethylase (CYP51)-catalyzed demethylation of lanosterol and possible reaction mechanism. The CYP51 belongs to the family of cytochrome P450 enzymes. The demethylation proceeds through two sequential monooxygenation reactions and subsequently a dehydroformylation. b Ring-opening and functionalization of cycloalkanols enabled by photoredox catalysis. c Possible mechanism for stearoyl Δ9 desaturation. d Recent notable work on dehydrogenation via photoredox cobaloxime dual catalysis. e Desaturation of alcohols and aliphatic C–H bond via PCET/cobaloxime dual catalysis.

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