Fig. 5: Analysis of data from all 45 animals and all three types of assays. | Nature Communications

Fig. 5: Analysis of data from all 45 animals and all three types of assays.

From: Differential V2-directed antibody responses in non-human primates infected with SHIVs or immunized with diverse HIV vaccines

Fig. 5

a Heatmap summarizing the humoral immune responses in immunized versus SHIV-infected NHPs. Immune responses shown in Figs. 3 and 4 and Supplementary Figs. S3–S6 were normalized and color-coded as indicated in the heatmap legend. Columns represent immune responses grouped according to Ab binding, C1q binding, and ADCP and are clustered within each parameter (Ab binding, C1q binding, or ADCP) measured using the antigens shown at the bottom of the heatmap. Rows represent single animals, each identified by number, vaccine regimen, or SHIV-strain used for infection. The heatmap is shown with hierarchical clustering according to the three dendrograms at the top and the one to the left. b, c Principal component analyses were performed using all values from panel a which are colored in panel b as immunized (pink) versus infected (blue), or in panel c, according to NHP groups as indicated in the legend. The axes show the Principal Component 1 and 2 (PC 1 and PC 2). The ellipses indicate 95% confidence interval of the means.

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