Fig. 1: ENSA is amplified at the 1.21.3 region, is highly expressed and predicts poor survival in TNBC. | Nature Communications

Fig. 1: ENSA is amplified at the 1.21.3 region, is highly expressed and predicts poor survival in TNBC.

From: Copy number amplification of ENSA promotes the progression of triple-negative breast cancer via cholesterol biosynthesis

Fig. 1

a Schematic diagram depicting the screening for copy number alteration-affected genes in TNBC. b Copy number alteration profile of the 1q21.3 region in the TCGA breast cancer cohort. c Kaplan–Meier survival analysis of 1q21.3 copy number alterations in TCGA breast cancer patients. Log-rank test. d 1q21.3 alteration frequency in the TCGA cohort with different breast cancer subtypes. e, f Kaplan–Meier plots of ENSA and GOLPH3L in TNBC or basal-like BC (https://kmplot.com/analysis/). Log-rank test. g ENSA expression of samples with different ENSA copy number in FUSCC and TCGA TNBC cohorts. n = 302 in FUSCC TNBC cohort and n = 153 in TCGA TNBC cohort. Data are presented as mean ± SD. Two-tailed one-way ANOVA tests and adjustments were made for multiple comparisons. h ENSA expression of 88 paired tumor tissues versus adjacent normal tissues in FUSCC cohort. n = 88 paired samples. Data are presented as mean ± SD. Two-tailed paired Student’s t test. Source data are provided as a Source Data file. FUSCC Fudan University Shanghai Cancer Center, TCGA The Cancer Genome Atlas, TNBC triple-negative breast cancer, BRCA breast cancer, FPKM fragments per kilobase million, RSEM RNA-seq by expectation maximization, Amp amplification, Norm normal.

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