Fig. 6: Overview model of transgenerational inheritance in response to lipid accumulation induced by the HFD. | Nature Communications

Fig. 6: Overview model of transgenerational inheritance in response to lipid accumulation induced by the HFD.

From: Histone H3K4me3 modification is a transgenerational epigenetic signal for lipid metabolism in Caenorhabditis elegans

Fig. 6

HFD can induce a TEI phenotype of lipid accumulation. In worms fed with HFD, the stress of lipid accumulation in the parent promotes the activity of sbp-1, daf-16, nhr-49, and nhr-80. Among them, only sbp-1 is involved in regulating histone H3K4me3 modification in a wdr-5.1-dependent manner and establishing the epigenetic marks in descendants. The upregulation of H3K4me3 modification promotes the recruitment and activation of daf-16 and sbp-1; simultaneously, the activation of daf-16 and sbp-1 might recruit nhr-49 or nhr-80, which then synergistically induce the expression of fat-5, fat-6 and fat-7 to respond lipid metabolism, thereby completing the TEI of obesity effect.

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