Fig. 2: Identification and regional distribution of lymphoid follicle, B cell-associated, and enteric nervous system signatures in the naive murine colon.
From: The spatial transcriptomic landscape of the healing mouse intestine following damage
a Heatmap of the top genes defining factors 1n, 3n and 9n enriched in B cell signature. b Spatial distribution of B cell-associated factors in the naive colon. c Immunohistochemical staining of CLU (enriched in lymphoid follicles) and JCHAIN (localized in the lamina propria) in healthy human colonic tissue (from Human Protein Atlas). d Functional enrichment analysis (Gene Ontology, GO) of factors 1n, 3n and 9n. e Top: spatial distribution (left) and top genes (right) defining factor 6n (enteric nervous system, ENS). Bottom: immunohistochemical staining of UCHL1 (neuronal marker) in the colonic submucosa of healthy human colonic tissue (from Human Protein Atlas). f Pathway analysis (GO) of factor 6n. g Schematic representation of spatial distribution of B cell factors (i.e. 1n, 3n and 9n from Panels A-D) and ENS-factor 6n (from Panel E-F).
