Fig. 3: Anti-SARS-CoV-2 spike T cell responses stratified by vaccine platform (BNT162b2 vs ChAdOx1 nCoV-19), biologic therapy (infliximab vs vedolizumab) and vaccine dose (one vs two).
a Spike MEP T cell responses SFC per 106 PBMC stratified by vaccine platform, biologic therapy (infliximab vs vedolizumab) and the number of vaccine doses. The horizontal bar represents the geometric mean and the narrow bars represent one geometric standard deviation on either side of the geometric mean. The number of T cell responders / total number of individuals tested are shown in black at the top of each panel. b Scatterplot demonstrating the correlation between T cell responses against spike MEP pool (SFC per 106 PBMC) and anti-SARS-CoV-2 spike antibody concentration after the first (LHS) and second (RHS) dose of BNT162B2 (top) and ChAdOx1 nCoV-19 (bottom) vaccine. The number of non-T cell responders/total number of individuals tested is shown in blue on the bottom RHS of each panel. The shaded grey band represents the 95% confidence interval. The horizontal dotted line in b represents a threshold of 15 U/mL of anti-S1 SARS-CoV-2 antibody. The tests were two-tailed and p values were reported without correction for multiple testing. The biologic infliximab is shown in green and vedolizumab is shown in orange. Source data are provided as a Source Data file. MEP mapped epitope peptide, SFC spot forming cells, PBMC peripheral blood mononuclear cell, LHS left-hand side, RHS right-hand side, R Spearman’s rank correlation.
