Fig. 6: RNA-protein correlated stratification of biological subgroups and clinical outcomes in TNBC.

a Comparison between TNBC proteomic clusters with published RNA-based TNBC subgroups. BLIA basal-immune activated, BLIS basal-immune suppressed, MES mesenchymal, LAR luminal androgen receptor²³. 35 cognate proteins identified from the 80 gene TNBC RNA classifier were used to generate the correlation heatmap based on the median expression of proteins for each TNBC subgroup. b Volcano plot showing proteins significantly associated with RFS in TNBC. Results are based on a Cox regression hazard model with a 2-sided log-rank p-value. Results were adjusted for multiple comparison using the Benjamini–Hochberg method. The x-axis is log2 hazard ratio (HR) and the y-axis is −log10 (p-value). Low (blue) and high (orange) HR’s indicate proteins associated with longer and shorter survival, respectively. The horizontal and vertical lines indicate p < 0.05, and log2HR > 0 or <0, respectively. The proteins and HR’s are listed in Supplementary Data 4. For visibility reasons only the top 20 proteins showing the lowest HR and highest HR with adjusted p-value < 0.05 were included in the plot. TNBC triple-negative breast cancer, RFS recurrence-free survival. Source data are provided as a Source Data file.