Fig. 8: Total synthesis of koumine-type alkaloids. | Nature Communications

Fig. 8: Total synthesis of koumine-type alkaloids.

From: Structure units oriented approach towards collective synthesis of sarpagine-ajmaline-koumine type alkaloids

Fig. 8

Key transformations are light induced radical reduction of iodide 25b and NIS mediated cyclization of 37 to access koumine-type alkaloids. [Ir(ppy)2(dtbbpy)]PF6 (4,4’-di-tert-butyl-2,2’-bipyridine)bis[(2-pyridinyl)phenyl]iridium(III) hexafluorophosphate, NIS N-iodosuccinimide, DIPEA N,N-Diisopropylethylamine.

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