Fig. 4: Chemogenetic inhibition of the PFC reduces ƴ activity but increases slow oscillatory power.
From: Increased fMRI connectivity upon chemogenetic inhibition of the mouse prefrontal cortex
a Mean post-injection spectrogram in control (left), hM4Di-expressing animals (center), and mean between group difference (right). b Quantification of band-specific power spectrum changes upon CNO injection in both groups (*q < 0.05, ***q < 0.001, two-sided Wilcoxon rank-sum tests followed by FDR correction, for n = 50 and n = 60 statistically independent recordings from n = 5 hM4Di and n = 5 control mice, respectively). c Example traces of band-passed δ-band LFPs and corresponding spiking activity (right) from a representative PFC recording channel during active phase in control and DREADD-expressing mice. Note the presence of greatly reduced, but more phase-locked firing in animals expressing hM4Di channel. d Violin plots depicting PLV of PFC spikes to slow and δ bands (***q < 0.001, two-sided Wilcoxon rank-sum tests followed by FDR correction for n = 79 and n = 80 statistically independent recordings from n = 5 hM4Di and n = 5 control mice, respectively). e Probability of firing (all sessions and datapoints) as a function of the phase angle of δ (bottom) and slow (top) bands. Phase conventions are such that 0 and 180 deg represent the peak and through of LFP, respectively. (Violin plots: thick lines represent median, dashed lines indicate 25th and 75th percentile, respectively). PLV phase-locking value. Source data are provided as a Source Data file.
