Fig. 5: Chemogenetic inhibition of the PFC results in increased interareal slow oscillatory coherence.
From: Increased fMRI connectivity upon chemogenetic inhibition of the mouse prefrontal cortex
Baseline-normalized power coherence at different frequency bands for PFC-retrosplenial (a), PFC-thalamus (b), and retrosplenial-thalamus (c) electrode pairs (*q < 0.05, ***q < 0.001, one-sided Wilcoxon rank-sum test, FDR corrected for n = 50 and n = 40 statistically independent recordings from n = 5 hM4Di and n = 4 control mice, respectively). d Band-specific coherence and mean functional connectivity (FC) difference (hM4Di – Control) for all pairs of electrophysiologically-probed regions. Mean FC data were extracted for corresponding regional pairs (Fig. 3) during the CNO active time window in hM4Di and control animals. e Correlation between corresponding band-specific coherence and mean functional connectivity for all pairs of electrophysiologically-probed regions (PFC-Rs; PFC-Th; Rs-Th). Shaded area indicates 95% CI for δ. f Baseline-normalized phase coherence in slow and delta band between electrode pairs (Violin plots: thick lines represent median, dashed lines indicate 25th and 75th percentile, respectively; ***q < 0.001, two-sided Wilcoxon rank-sum tests, FDR corrected). PFC prefrontal cortex, PLV phase-locking value, Rs retrosplenial cortex, Th thalamus. Source data are provided as a Source Data file.
