Fig. 6: A schematic illustration of our findings.
From: Increased fMRI connectivity upon chemogenetic inhibition of the mouse prefrontal cortex
Chemogenetically inhibiting neural activity in cortical node A (i.e. PFC) reduces high-frequency direct interactions between the manipulated region and its targets (B and C), concomitantly producing higher entrainment of residual spiking activity with ongoing global low-frequency oscillations (node C). Under the assumption (supported by our data) that rsfMRI interareal connectivity is primarily driven by low-frequency neural synchronization, this interpretative framework predicts both the observed increase in interareal slow and δ LFP coherence, and the corresponding increase in interareal rsfMRI connectivity.
