Fig. 2: Determining the epitopes for inhibitory and non-inhibitory antibodies targeting CyRPA.
From: Heterotypic interactions drive antibody synergy against a malaria vaccine candidate
Crystal structures of Fab fragments of Cy.002 (green), Cy.003 (yellow), Cy.004 (dark pink), and Cy.007 (light blue), each bound to CyRPA (blue). Within the inset box (bottom right) we show three different views of CyRPA, each rotated by 90°. The upper row “cartoon” images show the six blades of the CyRPA β-propeller. The lower row shows the CyRPA surface (blue) with binding epitopes indicated using the same colours as the antibody structures.
