Fig. 6: The reverse correlations between MIG-6 and ERBB2 proteins in the endometriosis baboon model.

a–c Immunohistochemical representative photomicrographs (a) and H-score (b) of MIG-6 (black) and ERBB2 (red) in the endometriosis baboon model induced by intraperitoneal inoculation of menstrual endometrium during progression of endometriosis in pre-inoculation, 3, 6, 9, and 15 months (n = 4 per period). Scale bars: 50 μm. c The reverse correlations between MIG-6 and ERBB2 proteins (Spearman correlation coefficient r = −0.6068, The two-tailed p value is 0.0046). d, e Average total number (d) and representative fluorescence photomicrographs (e) of endometriotic sites in control, Mig-6^d/d, Mig-6^d/dErbb2^d/d, and Erbb2^d/d mice by induced endometriosis based on mT/mG mice (n = 5 per genotype). Endometriotic lesions were visualized by GFP expression in the outside of uterus. White arrow indicates endometriotic lesions. Data are represented as mean ± SEM, *** p = 0.0003, *** p = 0.0002, and *** p < 0.0001 by Ordinary one-way ANOVA test. Scale bars: 1 cm. Three independent experiments were performed for a - e with similar results. Source data are provided in the Source Data file.