Fig. 8: Molecular mechanisms of MIG-6 function in the uterus.
From: Loss of MIG-6 results in endometrial progesterone resistance via ERBB2
MIG-6 mediates P4 inhibition of E2 signaling by inhibiting ErbB2-ERK signaling (Left side), and the attenuation of MIG-6 leads to ErbB2-ERK activation, proliferation of uterine epithelial cells, and eventually to endometriosis and infertility (Right side).
