Fig. 1: The hematopoietic landscape of human fetal liver at single-cell resolution. | Nature Communications

Fig. 1: The hematopoietic landscape of human fetal liver at single-cell resolution.

From: Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment

Fig. 1

a UMAP representation of the transcriptomic analysis of all four FL fractions combined showing the cell types identified in each cluster. Cells are colored by cell lineage annotation, developed using the expression of key markers and DEG from the transcriptomic analysis. Innate lymphoid cell precursor (pre ILC), erythroid-megakaryocyte-mast progenitor (EMMP), natural killer (NK) cell, plasmacytoid dendritic cell (pDC), dendritic cell precursor (DC precursor), hematopoietic stem cell/multipotent progenitor (HSC/MPP). This combined analysis represents different fractions isolated from one FL sample (Fig. S1). b UMAP representing the distribution of each FL fraction within the combined analysis. Cells are colored by the fraction of origin of each cell. c UMAP overlays illustrating mRNA expression patterns of a set of HSC/MPP and lineage markers. The scale bar applies to the scaled expression shown in panels c–e. d Re-analysis of data from Popescu et al. to illustrate the identified HSC/MPP signature in its original context14. e Overlay of HSC/MPP signature identified in Popescu et al. onto the combined transcriptomic analysis described in this study.

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