Fig. 3: Structural changes to S1 upon ACE2 binding.
From: Cooperative multivalent receptor binding promotes exposure of the SARS-CoV-2 fusion machinery core
a Schematic of the four geometric points (purple spheres) in S1 used to define the hinge dihedral and the cavity area. b, c Probability distributions of the hinge dihedral in each of the three structural states (closed, partially closed, and open) in the absence (N = 75003) and presence (N = 43800) of ACE2. d, e Probability distributions of the cavity area in each of the three structural states (closed, partially closed, and open) in the absence (N = 75003) and presence (N = 43800) of ACE2.
