Fig. 4: Cooperative enhancement of S2 trimeric core exposure by ACE2.
From: Cooperative multivalent receptor binding promotes exposure of the SARS-CoV-2 fusion machinery core
a Summary statistics for the fraction of S1 monomers bound to ACE2 (blue), S1 monomers dissociated from the spike trimer (red), and spike trimers with complete exposure of the S2 trimeric core (green) as the stoichiometric ratio of ACE2 dimers to spike trimers, [ACE2dimer]/[Strimer], is varied. b Hill plot comparing the natural log of the surface density of ACE2 (in #/nm2) to the natural log of the fraction of S1 monomers bound to ACE2 or the fraction of completely exposed S2 trimeric cores (Θ). The black and gray lines are fits to the Hill equation with Hill coefficients (nH) equal to 1.45 and 2.02. All data points report the mean and standard error from triplicate simulations.
