Fig. 6: Comparison between spike trimer S1/S2 cleavage states for the wild type (WT) CG model.
From: Cooperative multivalent receptor binding promotes exposure of the SARS-CoV-2 fusion machinery core
a Summary statistics for the difference in the probabilities of the closed (black), 1 RBD open (red), 2 RBD open (green), and 3 RBD open (blue) conformational states for the partially cleaved and completely cleaved spike trimer states (Puncleaved − Pcleaved) for WT virus. b Summary statistics for the difference in the fraction of S1 monomers bound to ACE2 (blue) and spike trimers with complete exposure of the S2 trimeric core (green) for the partially cleaved and completely cleaved spike trimer states (funcleaved − fcleaved) for WT virus; here, the stoichiometric ratio of ACE2 dimers to spike trimers is 2.56:1 (i.e., 64 ACE2 dimers to 25 spike trimers). In each simulation, the cleavage states are homogeneously distributed, e.g., the 66% cleaved system consists of 2 out of 3 cleaved protomers in every spike trimer. All data points report the mean and standard error from triplicate simulations.
