Fig. 6: Comparison of metabolic potential between enterotypes.
A Venn diagram showing qualitative overlap of KEGG orthology terms (KO) between treatment-relevant enterotypes. B Volcano plots highlight quantitative differences (differences in normalized counts) at the KO level between enterotypes. The comparison was performed using Deseq2 and P-values were adjusted for multiple testing bias using the Benjamini–Hochberg procedure. C Principal component analysis to display community-level differences of KO. A PERMANOVA analysis was conducted to quantify these differences. D Bar chart showing the average relative abundances of high-level KEGG pathways, by enterotype. For clarity, only proportions of sequences above 2% are shown. E Comparison between enterotypes of relative abundances of metabolic pathways associated with positive soil-transmitted helminth infection status in previous studies22,23,24. A Kruskal–Wallis test was used in combination with the Benjamini–Hochberg multiple testing bias corrections to identify differences and fold changes were calculated to show the corresponding effect sizes. ET1–3 enterotypes 1–3, FC fold change, Ref. Reference.
