Fig. 5: Forest plot of the rate of engraftment by vector type, i.e., (A) γRV, (B) LV, (C) SIN-γRV, and overall. | Nature Communications

Fig. 5: Forest plot of the rate of engraftment by vector type, i.e., (A) γRV, (B) LV, (C) SIN-γRV, and overall.

From: A systematic review and meta-analysis of gene therapy with hematopoietic stem and progenitor cells for monogenic disorders

Fig. 5

The squares indicate the rate of engraftment and their size reflects the study sample size, while the horizontal lines represent 95% Confidence Intervals (CI). The diamond denotes the summary effect size from the random-effects model for all or subgroups of studies (from a meta-regression model), and the width of the diamond depicts the overall 95% CI. The indices of heterogeneity (I2 and τ2) refer to the overall analysis or to the single subgroups, and pLRT is the p value for the test of residual heterogeneity, while pQM refers to the test on vector type as moderator. All tests were two-tailed. Source data are provided as a Source Data file.

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