Fig. 4: Release profiles and stability of the prepared microspheres.

a, b Release profiles of ATV, MPS, or HCT from AcDX (a) or PLGA (b) microspheres (n = 3). Data are presented as mean values ± SD. c–e X-ray powder diffractogram of drug-loaded AcDX microspheres, ATV@AcDX (c), MPS@AcDX (d) and HCT@AcDX (e), stored at 25 °C/40% relative humidity for 6 and 12 months. f–h X-ray powder diffractogram of drug-loaded PLGA microspheres, ATV@PLGA (f), MPS@PLGA (g), and HCT@PLGA (h), stored at 25 °C/40% relative humidity for 6 and 12 months.