Table 2 Genes associated with chemoresistance in both human B-ALL cell lines.

From: Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia

Genes associated with chemoresistance, signaling, and adhesion in both human B-ALL cell lines. REH & RCH-AcV (ACM + MTX); p-value cutoff of 0.05

Upregulated

LGALS9

ST3GAL6

LGALSL

LGALS1

LGALS3BP

LGALS8

CD44

CD69

ICAM1

ICAM2

ICAM3

ICAM4

ICAM5

PCDH1

PCDHGC3

PCDH9

CDH24

CDH2

ITGA4

ITGB1BP1

  1. This table contains genes identified as being associated with chemoresistance in both cell lines using a p-value cutoff of 0.05. The p-value cutoff of 0.05 was used to nominate upregulated genes associated with adhesion and aggregation which could be involved in the induction of chemoresistance. We chose to focus on Galectin-9 in this study because the LGALS9 gene validated in several human B-ALL cell lines and its surface expression was the only one consistently upregulated on human B-ALL cells (n = 8) cultured in adipocyte-conditioned medium.
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