Fig. 3: Distribution of P/LP germline mutations and the age at diagnosis.
From: Clinical and genomic features of Chinese lung cancer patients with germline mutations
a Bar plot indicated the prevalence of P/LP germline mutation (dark brown). The genes, number of patients, and mutation frequency of each gene are shown in the pie plot. Genes (SLX4, RUNX1, RAD51B, RAD51, PTCH2, NF1, MRE11A, GALNT12, FLCN, FANCC, FAM175A, CDH1, BARD1 and BAP1) with germline mutations detected in one patient were grouped as others. b Frequency of pathogenic and likely pathogenic germline variants in patients of different ages (n = 1715 patients with information on age of onset). Bar plot and lines shows the frequency of germline variants in patients under certain age (bar) and frequency in female and male patients (lines). c The panels show the age of onset for patients without germline mutations (n = 1611 patients) (light brown dots) and patients with different germline genes (n = 104 patients) (dark brown dots). Horizontal lines indicate median age. P value is calculated by the Mann–Whitney test (*p = 0.021, **p = 0.008).
