Fig. 4: Commonly somatic cancer gene mutations in lung cancer patients with and without germline variants.
From: Clinical and genomic features of Chinese lung cancer patients with germline mutations
a Genomic landscape of somatic mutation in patients with P/LP germline mutation. Stacked plots (top) show the number of somatic mutations (SNV/indels, CNV and SV) in each tumor sample (column). The gender, histology subtype and clinical stage are shown on the bottom. Bar plot on the right shows the mutation frequency of each gene. b Normalized bar plot illustrates the frequency of nine commonly mutated genes. Stripped bars represent patients with P/LP germline variants. Open bars represent patients without pathogenic germline variants. *Statistic difference between two cohorts: TP53, p = 0.016. KRAS, p = 0.015 and MET, p = 0.027. P value is calculated with Chi-square test (EGFR, TP53, KRAS) or Fisher’s exact test (c-MET, ALK, ROS-1, ERBB2, RET, BRAF).
