Fig. 4: Magnitude of SARS-CoV-2 specific Effector T cell Response.
From: Divergent trajectories of antiviral memory after SARS-CoV-2 infection
a Ex vivo IFN-γ ELISpot showing the effector T cell responses to summed SARS-CoV-2 peptide pools spanning spike, accessory and structural proteins (summed total of SARS-CoV-2 proteins tested, S1, S2, NSP3B, M, NP, ORF 3, ORF8 and the CEFT positive control peptides for T cell responses) in 78 individuals 28, 90 and 180 days after mild or asymptomatic SARS-CoV-2 infection (onset of symptoms for mild cases, PCR positive test for asymptomatic participants). The boxplots all display the median values with the first and third quartile, and the whiskers represent the highest and lowest values no more than 1.5 times the interquartile range from the corresponding hinge. A two-tailed Wilcoxon rank-sum test was used to compare between study time points (without correction for multiple testing). b Heatmap displaying unsupervised hierarchical clustering of the ELISpot data in a and disease severity (mild or asymptomatic) for the original SARS-CoV-2 diagnosis. Sfu/million PBMCs = spot forming units per million peripheral blood mononuclear cells, with background subtracted. D28, d90 and d180 = days after SARS-CoV-2 diagnosis. Grey regions on heatmap represent missing data due to insufficient cells.
