Fig. 4: Aggregation-enhanced imaging of bacteria in superficial tissues based on the proposed strategy.
From: Bacteria eat nanoprobes for aggregation-enhanced imaging and killing diverse microorganisms
a Schematic illustrating the mice with different treatments: PA (right side) and SA (left side), ~1.0 × 107 CFU during imaging (I); PA + SA, (right side) and PBS (left side), ~1.0 × 107 CFU during imaging (II); SA (right side) and PBS (left side), ~1.0 × 105 CFU during imaging (III); PA (right side) and PBS (left side), ~1.0 × 105 CFU during imaging (IV). b Corresponding fluorescence imaging and histograms of fluorescence intensity of different infected sites and (c), corresponding photoacoustic imaging and histograms of photoacoustic intensity of different infected sites with or without the irradiation of 405-nm laser. All imaging experiments were repeated three times with similar results. Statistical analysis was performed using a one-way ANOVA analysis. Error bars represent the standard deviation obtained from three independent measurements. Data are presented as mean values ± SD (*** means p < 0.001, **** means p < 0.0001, ns means no significance, n = 3). The cartoons are created by Dr. Houyu Wang. Source data are provided as a Source Data file.
