Fig. 4: Expression of α1A adrenoreceptors in BLA PV interneurons. | Nature Communications

Fig. 4: Expression of α1A adrenoreceptors in BLA PV interneurons.

From: Gq neuromodulation of BLA parvalbumin interneurons induces burst firing and mediates fear-associated network and behavioral state transition in mice

Fig. 4

a Coronal section of the brain showing β-galactosidase staining of α1A adrenoreceptor-expressing cells in the Adra1a KO mouse. 1-4 High-magnification images of areas indicated by dashed boxes showing the cortex (1), the hippocampus (2), the BLA (3), and the hypothalamus (4). Scale bar, 500 µm. b Colocalization of the β-gal signal with GFP expression in GABA interneurons in the BLA. Scale bar, 50 µm. c Mean (±SEM) percentage of total GAD67-positive cells in the BLA that were positive for β-gal (98.4 ± 0.18%, n = 302 cells in three sections from 2 mice). d Colocalization of the β-gal signal with mCherry expression in PV interneurons labeled by injection of Cre-dependent virus in PV-Cre mice. Scale bar, 50 µm. e Mean (±SEM) percentage of mCherry-labeled PV interneurons that were positive for β-gal (84.7 ± 2.46%, n = 134 cells in six sections from 2 mice).

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