Fig. 5: Burst firing in PV interneurons transforms BLA neural activity. | Nature Communications

Fig. 5: Burst firing in PV interneurons transforms BLA neural activity.

From: Gq neuromodulation of BLA parvalbumin interneurons induces burst firing and mediates fear-associated network and behavioral state transition in mice

Fig. 5

a A representative recording showing that chemogenetic activation of PV interneurons switches the firing pattern of PV cells from tonic to phasic. Below: Traces were expanded to show the tonic firing of the baseline and burst firing after CNO application. b Raster plots of spiking activity in recordings from 7 PV interneurons (from 3 mice) that show the transformation of tonic spiking to phasic spiking by CNO. c Representative interspike interval (ISI) histogram of the cell shown in a. d, e Gq activation increased the predominant firing rate (d) and the ISI coefficient of variation (e) in the BLA PV interneurons (mean ± SEM, n = 7 cells from three mice, paired t-tests (two-tailed): predominant firing rate, CNO vs. baseline, p = 0.013; ISI coefficient of variation, CNO vs. baseline, p = 0.0006, *p < 0.05, **p < 0.01). f A representative current-clamp recording from a principal neuron showing that Gq activation in PV cells transforms the firing pattern of a BLA principal neuron from tonic to phasic. g Raster plots of spiking activity in recordings from seven principal neurons (from 3 mice) that show the transformation of tonic spiking to phasic spiking by CNO. Source data are provided as a Source Data file.

Back to article page