Fig. 1: T/NM mismatch by clustering of the whole cohort. | Nature Communications

Fig. 1: T/NM mismatch by clustering of the whole cohort.

From: Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer’s disease

Fig. 1

a Schematic of proposed relationship between tau (T) and neurodegeneration (N) by neuronal hypometabolism (NM). b Regression model of 18F-FDG vs. log tau SUVR in the inferior temporal gyrus, a typical tau staging region in AD. Solid line represents the model, with dashed lines denoting standard deviation-based thresholds (n = 289 participants). NM < T denotes points above the line and NM > T depicts points below the line. Circles are A+. Diamonds are A− participants. Source data are provided as a Source Data file. Consistent clustering by T/NM mismatch of all regional and patient residuals is visually demonstrated by (c) principal component analysis and (d) dendrogram.

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