Table 2 T/NM mismatch clustering across A+ patients.

From: Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer’s disease

Group

MCI/Dem

F/M

Age (y)

Educ (y)

Cognition

Cortical thickness (mm)

ADAS-Cog

CDR-SOB

MMSE

High cortical resilient

19/4

11/12

74.5 (6.8)

16.5 (2.5)

22.5 (8.6)

2.0 (1.8)

27.1 (3.4)

2.05 (0.25)

Limbic resilient

5/2

4/3

70.4 (11.5)

15.6 (2.3)

23.5 (9.0)

2.4 (1.2)

24.7 (4.7)

1.95 (0.42)

Low cortical resilient

31/5

20/16

73.4 (7.4)

15.0 (2.1)

20.7 (5.8)**

2.0 (1.8)+

27.1 (2.2)**

2.08 (0.22)**

Canonical

26/23

19/30

75.6 (7.4)

16.6 (3.6)

26.5 (8.4)

3.0 (2.2)

25.6 (3.1)

1.77 (0.57)

Cortical susceptible

14/17

10/21

74.3 (15.6)

15.6 (3.1)

28.4 (8.4)

4.0 (2.5)+

24.2 (3.6)

1.78 (0.41)

Limbic susceptible

7/11

11/7

78.8 (5.3)

15.7 (2.2)

28.0 (9.6)

3.3 (2.5)

24.7 (4.4)

1.64 (0.44)

Group p val

 

0.03

0.36

0.01

<0.0001

0.01

<0.05

0.005

  1. Diagnosis (MCI/dementia) and sex (F/M) are in frequencies. Mean (standard deviation) values are shown for age/education (years), ADAS-Cog, CDR-SOB, MMSE, and global cortical thickness (mm). The last row depicts group difference p values by likelihood ratio tests after adjusting for covariates. Significant differences in pairwise comparisons between a non-canonical and canonical group with covariate adjustment are annotated. For pairwise comparisons, ** denotes p < 0.005 after multiple tests adjustment and + denotes p < 0.05 before multiple tests adjustment. Covariates include sex, age, education and inferior temporal gyrus tau SUVR. Sample sizes and p values are listed in Supplementary Data 1.
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