Fig. 8: Core TFs regulate LSC function and identity by SE–P interaction networks.

a Schematic of TF motif enrichment analysis. b Identified TF motifs in the indicated groups. c Metaplots and heatmaps showing the enrichment of the indicated ChIP-Seq signals at the CTCF and SMC1 sites. d Metaplots showing the enrichment of p63 and RPS at promoter-anchored enhancers and enhancer-anchored promoters. e Chromatin interactions between p63-bound enhancers and selected genes. Blue nodes represent p63-bound enhancers and orange nodes represent target genes. Edges represent chromatin interactions. f Identified chromatin interactions and tracks for the indicated ChIP-Seq signals at NOTCH1 locus. g Metaplot and heatmap showing the enrichment of p63 at SEs. h Identified chromatin interactions and tracks for the indicated ChIP-Seq signals at ITGB4 locus. i p63 and RPS mediated an intersected gene regulatory network via SE–P interactions.