Fig. 9: A model of 3D regulatory network organized into the multi-hierarchical genome architectures in LSCs.
From: Comprehensive 3D epigenomic maps define limbal stem/progenitor cell function and identity
Genome is organized into compartment A and B that contain active and inactive TADs, respectively. In the active TADs, SEs interact with other SEs and/or target promoters, forming intersected SE 3D interaction hubs that are constrained within cohesion-associated CTCF-CTCF loops. p63 and RPS activate LSC identity genes by binding SEs that interact with target promoters. p63 and RPS establish a coordinated regulatory network through SE-P interactions. In the inactive TADs, super-silencers repress genes associated with development, differentiation, neural fate, and disease via proximity and/or chromatin interactions.
