Table 1 AOA and COA nasal epithelium TWAS genes.
Childhood Onset Asthma | Adult Onset Asthma | Nasal Specific? | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. | Gene | Position (Hg38) | HSQ | TWAS.Z | TWAS.P | PP3 | PP4 | TWAS.Z | TWAS.P | PP3 | PP4 | |
Childhood Onset Asthma | ||||||||||||
1 | LOC115110 | 1:2549920-2557011 | 0.46 | 4.63 | 3.73E-06 | 0.02 | 0.98 | 3.15 | 1.65E-03 | NA | NA | Y |
2 | RIIAD1 | 1:151721537-151729606 | 0.54 | -5.99 | 2.09E-09 | 1.00 | 0.00 | -1.87 | 6.12E-02 | NA | NA | Y |
3 | MRPL9 | 1:151759643-151763916 | 0.14 | -5.96 | 2.45E-09 | 1.00 | 0.00 | -1.70 | 8.82E-02 | NA | NA | Y |
4 | LINGO4 | 1:151800265-151805442 | 0.42 | 7.21 | 5.39E-13 | 1.00 | 0.00 | 0.88 | 3.77E-01 | NA | NA | N |
5 | FLG-AS1 | 1:152313459-152366692 | 0.31 | -7.00 | 2.60E-12 | 1.00 | 0.00 | -1.52 | 1.29E-01 | NA | NA | N |
6 | FCER1G | 1:161215297-161219248 | 0.19 | 6.40 | 1.57E-10 | 0.00 | 1.00 | 3.70 | 2.12E-04 | NA | NA | N |
7 | IL1R2 | 2:101991844-102028422 | 0.07 | -6.27 | 3.57E-10 | 0.99 | 0.00 | -3.81 | 1.41E-04 | NA | NA | Y |
8 | SLC9A4 | 2:102473303-102533972 | 0.21 | -7.50 | 6.55E-14 | 1.00 | 0.00 | -4.38 | 1.18E-05 | NA | NA | Y |
9 | RFTN2 | 2:197570803-197675860 | 0.31 | -4.77 | 1.86E-06 | 0.07 | 0.93 | -4.06 | 4.87E-05 | NA | NA | N |
10 | NEU4 | 2:241809065-241817413 | 0.49 | 6.67 | 2.51E-11 | 1.00 | 0.00 | 2.92 | 3.55E-03 | NA | NA | Y |
11 | CCDC66 | 3:56557156-56621820 | 0.50 | -4.69 | 2.75E-06 | 0.08 | 0.92 | -3.12 | 1.82E-03 | NA | NA | Y |
12 | EAF2 | 3:121835187-121886526 | 0.10 | -5.16 | 2.48E-07 | 0.50 | 0.50 | -2.73 | 6.41E-03 | NA | NA | N |
13 | SLC15A2 | 3:121894324-121944187 | 0.46 | 5.61 | 2.02E-08 | 0.15 | 0.85 | 2.89 | 3.80E-03 | NA | NA | Y |
14 | RUVBL1 | 3:128080957-128123828 | 0.29 | -5.18 | 2.22E-07 | 0.97 | 0.03 | -2.28 | 2.26E-02 | NA | NA | Y |
15 | TIPARP | 3:156674416-156706768 | 0.08 | 5.08 | 3.72E-07 | 0.15 | 0.84 | 2.56 | 1.05E-02 | NA | NA | Y |
16 | FAM114A1 | 4:38867733-38945744 | 0.13 | -5.58 | 2.34E-08 | 0.37 | 0.06 | 1.39 | 1.64E-01 | NA | NA | N |
17 | NFKB1 | 4:102501329-102617302 | 0.40 | -4.93 | 8.35E-07 | 0.21 | 0.79 | -1.37 | 1.71E-01 | NA | NA | Y |
18 | IL7R | 5:35856875-35879603 | 0.07 | -4.95 | 7.49E-07 | 0.17 | 0.69 | -2.81 | 4.99E-03 | NA | NA | Y |
19 | LOC553103 | 5:132311276-132369916 | 0.43 | -4.76 | 1.91E-06 | 1.00 | 0.00 | -3.61 | 3.12E-04 | NA | NA | Y |
20 | SLC22A5 | 5:132369709-132395614 | 0.37 | 5.03 | 4.86E-07 | 1.00 | 0.00 | 3.16 | 1.60E-03 | NA | NA | N |
21 | SEPT8 | 5:132750817-132777869 | 0.12 | 6.24 | 4.43E-10 | 1.00 | 0.00 | 4.11 | 3.90E-05 | NA | NA | N |
22 | RGS14 | 5:177357843-177372598 | 0.50 | -4.89 | 1.02E-06 | 0.26 | 0.73 | -2.96 | 3.05E-03 | NA | NA | N |
23 | ITGB8 | 7:20331102-20415759 | 0.08 | -5.73 | 1.02E-08 | 0.64 | 0.29 | -3.81 | 1.40E-04 | NA | NA | Y |
24 | JAZF1 | 7:27830574-28180818 | 0.19 | 4.89 | 1.02E-06 | 1.00 | 0.00 | 2.92 | 3.45E-03 | NA | NA | Y |
25 | ERMP1 | 9:5784572-5833081 | 0.38 | 5.80 | 6.67E-09 | 1.00 | 0.00 | 4.23 | 2.35E-05 | NA | NA | Y |
26 | HHEX | 10:92689924-92695651 | 0.25 | 6.98 | 2.90E-12 | 0.02 | 0.98 | 4.60 | 4.19E-06 | NA | NA | Y |
27 | WBP1L | 10:102743970-102816264 | 0.40 | 4.80 | 1.55E-06 | 1.00 | 0.00 | 0.96 | 3.37E-01 | NA | NA | Y |
28 | SYT13 | 11:45240302-45286333 | 0.45 | -4.86 | 1.15E-06 | 0.03 | 0.97 | -2.88 | 3.99E-03 | NA | NA | Y |
29 | MYO7A | 11:77128264-77215241 | 0.12 | 5.18 | 2.21E-07 | 0.99 | 0.00 | 3.08 | 2.09E-03 | NA | NA | Y |
30 | AAMDC | 11:77821162-77872352 | 0.05 | -5.00 | 5.83E-07 | 0.26 | 0.56 | -1.06 | 2.87E-01 | NA | NA | Y |
31 | RPS26 | 12:56041902-56044223 | 0.33 | 6.87 | 6.58E-12 | 1.00 | 0.00 | 4.59 | 4.54E-06 | NA | NA | N |
32 | NABP2 | 12:56224341-56229854 | 0.07 | -5.99 | 2.06E-09 | 0.63 | 0.03 | -4.45 | 8.69E-06 | NA | NA | Y |
33 | SPPL3 | 12:120762510-120904352 | 0.19 | 7.54 | 4.86E-14 | 0.97 | 0.03 | 2.79 | 5.27E-03 | NA | NA | N |
34 | ABCB9 | 12:122920951-122966509 | 0.14 | -4.74 | 2.18E-06 | 0.96 | 0.05 | -0.76 | 4.45E-01 | NA | NA | N |
35 | CDK2AP1 | 12:123260970-123272316 | 0.44 | 5.26 | 1.41E-07 | 0.48 | 0.52 | 0.86 | 3.87E-01 | NA | NA | N |
36 | BAHD1 | 15:40439721-40468242 | 0.05 | 4.74 | 2.19E-06 | 0.62 | 0.08 | 0.83 | 4.07E-01 | NA | NA | Y |
37 | CHP1 | 15:41231239-41281885 | 0.33 | -6.04 | 1.53E-09 | 0.79 | 0.21 | -2.73 | 6.26E-03 | NA | NA | N |
38 | OIP5-AS1 | 15:41284003-41299597 | 0.19 | -4.69 | 2.70E-06 | 0.87 | 0.13 | -1.35 | 1.78E-01 | NA | NA | N |
39 | ITPKA | 15:41493858-41503559 | 0.21 | 5.36 | 8.54E-08 | 0.01 | 0.99 | 2.83 | 4.72E-03 | NA | NA | Y |
40 | IQGAP1 | 15:90388241-90502243 | 0.41 | -5.27 | 1.34E-07 | 0.01 | 0.99 | -1.10 | 2.72E-01 | NA | NA | N |
41 | DEXI | 16:10928891-10942400 | 0.32 | -7.41 | 1.23E-13 | 1.00 | 0.00 | -2.91 | 3.66E-03 | NA | NA | Y |
42 | NSMCE1 | 16:27224994-27268792 | 0.26 | 7.19 | 6.65E-13 | 1.00 | 0.00 | 3.11 | 1.84E-03 | NA | NA | Y |
43 | IL4R | 16:27313909-27364778 | 0.17 | 5.36 | 8.17E-08 | 0.66 | 0.33 | 2.59 | 9.49E-03 | NA | NA | N |
44 | ATP2A1 | 16:28878488-28904509 | 0.08 | -4.62 | 3.80E-06 | 0.30 | 0.66 | -0.97 | 3.33E-01 | NA | NA | Y |
45 | LINC00672 | 17:38925168-38929384 | 0.10 | 6.78 | 1.19E-11 | 0.63 | 0.01 | -1.31 | 1.89E-01 | NA | NA | Y |
46 | MED1 | 17:39404285-39451274 | 0.17 | 8.20 | 2.46E-16 | 1.00 | 0.00 | -0.11 | 9.16E-01 | NA | NA | Y |
47 | STARD3 | 17:39637080-39664201 | 0.35 | 14.75 | 3.30E-49 | 1.00 | 0.00 | 2.05 | 4.07E-02 | NA | NA | N |
48 | PGAP3 | 17:39671122-39688070 | 0.61 | 15.28 | 9.73E-53 | 1.00 | 0.00 | 1.54 | 1.24E-01 | NA | NA | N |
49 | ERBB2 | 17:39688084-39728662 | 0.32 | 13.38 | 7.45E-41 | 1.00 | 0.00 | 0.48 | 6.33E-01 | NA | NA | N |
50 | GRB7 | 17:39737909-39747285 | 0.09 | 10.14 | 3.85E-24 | 0.99 | 0.00 | -2.49 | 1.29E-02 | NA | NA | Y |
51 | IKZF3 | 17:39757715-39864188 | 0.11 | -18.26 | 1.70E-74 | 0.42 | 0.58 | -4.54 | 5.66E-06 | NA | NA | Y |
52 | GSDMB | 17:39904595-39918650 | 0.52 | 23.68 | 5.47E-124 | 0.01 | 0.99 | 2.71 | 6.70E-03 | NA | NA | N |
53 | GSDMA | 17:39962973-39977766 | 0.34 | -13.40 | 5.74E-41 | 1.00 | 0.00 | -2.93 | 3.43E-03 | NA | NA | N |
54 | PSMD3 | 17:39980768-39997960 | 0.06 | 11.33 | 9.54E-30 | 1.00 | 0.00 | 2.18 | 2.95E-02 | NA | NA | Y |
55 | MED24 | 17:40019097-40054636 | 0.45 | 5.46 | 4.73E-08 | 1.00 | 0.00 | 0.02 | 9.85E-01 | NA | NA | N |
56 | RARA-AS1 | 17:40340867-40343136 | 0.06 | 5.84 | 5.11E-09 | 0.98 | 0.01 | 1.63 | 1.04E-01 | NA | NA | Y |
57 | STAT5A | 17:42287547-42311942 | 0.13 | -4.69 | 2.76E-06 | 0.72 | 0.28 | -3.43 | 5.95E-04 | NA | NA | Y |
58 | HEXIM1 | 17:45147317-45152101 | 0.27 | -6.01 | 1.80E-09 | 1.00 | 0.00 | -1.24 | 2.14E-01 | NA | NA | Y |
59 | SPATA32 | 17:45254393-45262112 | 0.73 | -5.21 | 1.88E-07 | 0.98 | 0.02 | -2.71 | 6.67E-03 | NA | NA | N |
60 | LRRC37A4P | 17:45505883-45520523 | 0.32 | 5.66 | 1.55E-08 | 1.00 | 0.00 | 0.17 | 8.64E-01 | NA | NA | N |
61 | LOC644172 | 17:45600103-45601862 | 0.10 | -5.71 | 1.16E-08 | 1.00 | 0.00 | -0.46 | 6.44E-01 | NA | NA | Y |
62 | MGC57346 | 17:45620329-45637963 | 0.22 | -5.52 | 3.34E-08 | 1.00 | 0.00 | -0.39 | 6.97E-01 | NA | NA | Y |
63 | CRHR1-IT1 | 17:45638975-45646229 | 0.26 | -5.63 | 1.82E-08 | 1.00 | 0.00 | -0.42 | 6.78E-01 | NA | NA | N |
64 | MAPT | 17:45894382-46028333 | 0.11 | 4.84 | 1.32E-06 | 1.00 | 0.00 | -0.09 | 9.29E-01 | NA | NA | N |
65 | KANSL1 | 17:46029916-46225374 | 0.14 | -5.19 | 2.06E-07 | 1.00 | 0.00 | -0.18 | 8.55E-01 | NA | NA | N |
66 | KANSL1-AS1 | 17:46193573-46196723 | 0.29 | -5.22 | 1.75E-07 | 1.00 | 0.00 | -0.07 | 9.47E-01 | NA | NA | N |
67 | LRRC37A | 17:46295131-46337794 | 0.40 | -6.01 | 1.85E-09 | 1.00 | 0.01 | -0.16 | 8.72E-01 | NA | NA | N |
68 | ZNF652 | 17:49289206-49362473 | 0.46 | -5.72 | 1.07E-08 | 0.97 | 0.03 | -3.31 | 9.29E-04 | NA | NA | Y |
69 | SPOP | 17:49598884-49678163 | 0.08 | 5.03 | 4.87E-07 | 0.60 | 0.02 | 4.09 | 4.25E-05 | NA | NA | Y |
70 | SMAD4 | 18:51030213-51085041 | 0.25 | -6.63 | 3.43E-11 | 0.06 | 0.94 | -2.50 | 1.25E-02 | NA | NA | N |
71 | POLI | 18:54269479-54298234 | 0.52 | 6.28 | 3.49E-10 | 0.41 | 0.60 | 3.07 | 2.17E-03 | NA | NA | N |
72 | MUC16 | 19:8848844-8981342 | 0.25 | -6.66 | 2.69E-11 | 0.05 | 0.96 | -2.77 | 5.53E-03 | NA | NA | Y |
73 | FOXA3 | 19:45864260-45873797 | 0.42 | 5.12 | 3.13E-07 | 0.03 | 0.97 | 4.24 | 2.22E-05 | NA | NA | Y |
74 | STMN3 | 20:63639705-63653610 | 0.23 | -5.23 | 1.65E-07 | 0.03 | 0.97 | -3.36 | 7.75E-04 | NA | NA | N |
75 | LIME1 | 20:63735701-63739107 | 0.18 | 4.74 | 2.14E-06 | 0.72 | 0.28 | 3.00 | 2.66E-03 | NA | NA | Y |
76 | RANGAP1 | 22:41244777-41286251 | 0.21 | 5.20 | 2.00E-07 | 0.58 | 0.42 | 2.59 | 9.63E-03 | NA | NA | N |
77 | TOB2 | 22:41433488-41447023 | 0.05 | -6.02 | 1.74E-09 | 0.05 | 0.95 | -3.87 | 1.09E-04 | NA | NA | Y |
78 | PHF5A | 22:41459717-41468704 | 0.05 | 5.92 | 3.22E-09 | 0.27 | 0.73 | 4.15 | 3.34E-05 | NA | NA | Y |
79 | XRCC6 | 22:41621163-41664048 | 0.04 | -5.03 | 4.80E-07 | 0.34 | 0.59 | -2.83 | 4.60E-03 | NA | NA | N |
80 | C22orf46 | 22:41690543-41698136 | 0.13 | -4.78 | 1.76E-06 | 0.84 | 0.16 | -2.65 | 7.96E-03 | NA | NA | Y |
81 | MEI1 | 22:41699514-41799455 | 0.16 | 4.66 | 3.20E-06 | 0.86 | 0.14 | 2.80 | 5.19E-03 | NA | NA | N |
Shared | ||||||||||||
82 | IL18R1 | 2:102356283-102398775 | 0.08 | -9.16 | 5.05E-20 | 0.54 | 0.05 | -5.31 | 1.11E-07 | 0.56 | 0.02 | N |
83 | D2HGDH | 2:241734579-241768816 | 0.64 | 10.31 | 6.63E-25 | 1.00 | 0.00 | 6.61 | 3.85E-11 | 1.00 | 0.00 | N |
84 | GAL3ST2 | 2:241776825-241804287 | 0.43 | 8.87 | 7.02E-19 | 1.00 | 0.00 | 6.83 | 8.41E-12 | 1.00 | 0.00 | Y |
85 | TSLP | 5:111070080-111078024 | 0.34 | 14.68 | 8.88E-49 | 1.00 | 0.00 | 10.29 | 7.77E-25 | 1.00 | 0.00 | N |
86 | PDLIM4 | 5:132257658-132273454 | 0.17 | 7.17 | 7.77E-13 | 1.00 | 0.00 | 7.97 | 1.64E-15 | 0.99 | 0.01 | N |
87 | MIR3936 | 5:132365490-132365599 | 0.09 | -5.74 | 9.74E-09 | 1.00 | 0.00 | -4.98 | 6.52E-07 | 1.00 | 0.00 | Y |
88 | RAD50 | 5:132556924-132644621 | 0.12 | -8.41 | 4.00E-17 | 0.83 | 0.02 | -7.74 | 9.91E-15 | 0.10 | 0.89 | N |
89 | BACH2 | 6:89926528-90296908 | 0.09 | 5.73 | 1.01E-08 | 0.14 | 0.84 | 5.15 | 2.61E-07 | 0.14 | 0.84 | Y |
90 | IL33 | 9:6215786-6257983 | 0.25 | 18.84 | 3.67E-79 | 0.00 | 1.00 | 12.41 | 2.18E-35 | 0.01 | 0.99 | Y |
91 | RAB5B | 12:55973913-55996683 | 0.05 | 6.23 | 4.57E-10 | 0.42 | 0.15 | 6.25 | 4.22E-10 | 0.07 | 0.86 | Y |
92 | UBAC2-AS1 | 13:99196374-99200757 | 0.09 | 5.96 | 2.56E-09 | 0.14 | 0.86 | 5.51 | 3.62E-08 | 0.28 | 0.72 | Y |
93 | UBAC2 | 13:99200425-99386499 | 0.29 | -6.60 | 4.20E-11 | 0.04 | 0.96 | -4.98 | 6.32E-07 | 0.20 | 0.80 | Y |
Adult Onset Asthma | ||||||||||||
94 | RERE | 1:8352404-8817640 | 0.14 | 4.30 | 1.71E-05 | NA | NA | 4.91 | 8.90E-07 | 0.02 | 0.98 | N |
95 | ZDHHC18 | 1:26826710-26855720 | 0.07 | 1.27 | 2.04E-01 | NA | NA | 4.62 | 3.85E-06 | 0.09 | 0.86 | N |
96 | LOC100130476 | 6:137823670-137868233 | 0.08 | 2.60 | 9.38E-03 | NA | NA | 4.67 | 3.07E-06 | 0.29 | 0.70 | Y |
97 | C7orf26 | 7:6590021-6608726 | 0.06 | 2.03 | 4.20E-02 | NA | NA | 4.96 | 7.05E-07 | 0.23 | 0.47 | Y |
98 | MUC2 | 11:1074875-1110508 | 0.21 | -2.10 | 3.56E-02 | NA | NA | -5.24 | 1.65E-07 | 0.02 | 0.98 | Y |
99 | MUC5AC | 11:1157953-1201141 | 0.32 | 2.74 | 6.21E-03 | NA | NA | 7.22 | 5.13E-13 | 0.02 | 0.98 | Y |
100 | FADS1 | 11:61799625-61817057 | 0.32 | 1.62 | 1.05E-01 | NA | NA | 6.49 | 8.49E-11 | 0.04 | 0.96 | Y |
101 | SIK2 | 11:111602391-111726917 | 0.27 | -2.63 | 8.44E-03 | NA | NA | -5.06 | 4.10E-07 | 0.21 | 0.79 | N |
102 | HDAC7 | 12:47782711-47819980 | 0.16 | -0.98 | 3.29E-01 | NA | NA | -4.62 | 3.92E-06 | 0.39 | 0.60 | Y |
