Fig. 6: In OPC-GABA_BR cKO mice a perturbed neuronal firing translates into deficits of social behavior.

a Experimental schedule. b Lower gamma band acquired by electroencephalogram recordings. c Violin plot shows decreased gamma oscillation in the cKO mouse brain. (ctl = 24 h from 4 mice, cKO = 24 h from 4 mice, two-sided unpaired t-tests). d Impaired nest building ability of mutant mice. (male: ctl = 10 mice, cKO = 10 mice; female: ctl = 15 mice, cKO = 10 mice, two-sided unpaired t-test). e Scheme of the three-chamber behavior test. f Quantification of the sniffing time with mouse (M) and object (O) (male: ctl = 9 mice, cKO = 9 mice, two-sided paired t-tests; female: ctl = 15 mice, cKO = 9 mice, two-sided paired t-tests). g Quantification of the sniffing time with familiar (F) and stranger (S) mouse (male: ctl = 9 mice, cKO = 9 mice, two-sided paired Wilcoxon test; female: ctl = 15 mice, cKO = 9 mice, two-sided paired t-test). h Scheme of new object recognition test. i Assessment of object preference (male: ctl = 10 mice, cKO = 10 mice; female: ctl = 15 mice, cKO = 9 mice, two-sided unpaired t-test). j Percentage of sniffing time with new object among total sniffing time. (male: ctl = 10 mice, cKO = 10 mice; female: ctl = 15 mice, cKO = 9 mice, two-sided unpaired t-test). k Representative trajectory charts of the animals during the open field test. l, m Both ctl and cKO mice exhibited similar motor activities shown by the speed and distance analysis. (male: ctl = 17 mice, cKO = 14 mice; female: ctl = 18 mice, cKO = 9 mice, two-sided unpaired t-test). Data are shown as mean ± SEM in d, i, j, l and m. In c, data are shown with indications of median and quartiles in thick and thin dashed lines, respectively. Source data are provided as a Source Data file.